From the CEO
“I have personal experience on how devastating a brain disorder that changes your behavior and personality can be. My mother, who died in 2014, suffered from Alzheimer’s. My personal commitment is to develop a cure for Alzheimer’s disease, no matter what this may cost. There is no plan B.”
- Nikolaos Tezapsidis
Problem
Alzheimer’s disease affects more than 5 million Americans and 40 million patients worldwide.
Current medications provide limited relief. Many of our competitors are focusing on removing either Abeta or tau deposits from the brain where they form plaques and tangles. None of these efforts have generated any effective drug for the last 18 years since the first anti-Abeta trial started.
The idea that Abeta and plaque do not cause Alzheimer’s is gaining momentum in the research community. We were determined to look for a different solution prior to the formation of the plaques.
Industry Snapshot
“Alzheimer’s disease market will more than double to $11.3 Billion by 2021.” GBI Research
Solution
Our novel approach focuses on Leptin, a naturally occurring human hormone associated with various metabolic effects, has a large number of receptors in memory centers of the brain.
Hippocampus (in red) responsible for memory formation, cognition and executive function is severely affected by the disease. This region is rich in Leptin receptors.
This protein is often present at decreased levels in patients suffering from Alzheimer’s disease, and cognitive deterioration in AD patients correlates strongly with a decline in circulating Leptin levels.
We are developing Memtin™ to treat Leptin deficiency in Alzheimer’s patients. This Leptin product will act as a novel hormone replacement therapy for Alzheimer’s disease (AD) and/or as a preventative for those who are at risk.
Success
Recognition
- InvestAcure Coin Award 2019
- InvestAcure honored Nik Tezapsidis with the Cure Coin Award for his work in the development of Memtin, a novel recombinant human Leptin product, used as a hormone replacement therapy, showing potential in both slowing down and preventing Alzheimer’s.
- Nominated for Most Promising Private Company 2015
- The Biotechnology Industry Organization nominated Neurotez, Inc. as a Most Promising Private Company for its 2015 Buzz of Bio Contest.
- Best Presentation Award at NYC Venture Summit 2011
- A panel of judges consisting of venture capitalists, private investors and other business executives at the NYC Venture Summit 2011, voted Neurotez’s presentation as the best among 30 companies in the Life sciences category.
- 2010 Incubator Company to Watch
- Neurotez was chosen as a 2010 Incubator Company to Watch at the NJTC Gala Awards
Team
Operating Team
An impressive group of exceptional individuals with deep experience and success in their respective fields in Academia (1000s of publications in Alzheimer’s) and Pharmaceutical Industry have been working together for a number of years to achieve our mission.
- PhD in Biochemistry at the University of Sussex, UK
- 18+ years of biomedical research
- Two awards from the Alzheimer’s Association
- MD and PhD in Neuroscience from UCLA
- 100+ publications on Alzheimer’s disease
- Senior Research Scientist at the Stanford/VA Aging Clinical Research Center and Alzheimer’s Center
- PhD in Marine Biology from Scripps Institution of Oceanography
- 1,000+ publications on Alzheimer's disease
- Semmes Foundation Endowed Chair in Neurobiology at the University of Texas at San Antonio
- PhD in Microbial Biochemistry at University of Cambridge
- 33 years of drug development experience at Pfizer
- 50+ publications and patents
- 25+ years of pharma experience in US, Canada, and Europe
- Authored 55 original publications in top-rated international medical journals
- Member of International Science Advisory Board
- PhD in Biochemistry from Imperial College
- 18+ years of research experience in neural repair and cellular imaging
- Principal Investigator for the University of Medicine and Dentistry of New Jersey and Albert Einstein College of Medicine
- MS in Clinical Pharmacology from Thomas Jefferson University
- Extensive experience in early phase clinical development, regulatory affairs, and life-cycle management
- Worked at Bristol-Myers Squibb, Wyeth, and Johnson & Johnson
- MBA in Marketing from the Haub School of Business at Saint Joseph’s University
- President and CEO of Otsuka America Pharmaceutical, Inc.
- VP and Global Business Manager for Oncology at Wyeth
- MBA in Finance from Long Island University
- CEO of Healthcare Economics LLC
- VP at Dragon Pharmaceuticals, Inc.
- 36 years of experience in Pharma and Biotech
- 225+ papers published
- Retired as a Colonel after 26 years in the Navy and Airforce
Memtin™ Development Timeline
Previous Funding
Total = $4.5M
National Institutes of Health
IRS Qualifying Therapeutic Discovery Project grant
New Jersey Commission of Science and Technology
Pitch Deck
More Info
- Website: neurotez.com
- Facebook: facebook.com/neurotez
- Twitter: twitter.com/Neurotez
Use of Proceeds
To be used for General Corporate purposes including legal, accounting, marketing, and salary expenses.
If the offering's maximum Reg CF allocation of $500,000 is raised:
| Use | Value | % of Proceeds |
|---|---|---|
| Manufactuirng and IND-enabling studies for Leptin product | $200,000 | 40.0% |
| Phase 1A/1B clinical trials | $200,000 | 40.0% |
| Personnel costs | $25,500 | 5.1% |
| Debt repayment | $50,000 | 10.0% |
| Intermediary fees | $24,500 | 4.9% |
If the offering's maximum amount of $2,500,000 across Reg. CF and Reg. D is raised:
| Use | Value | % of Proceeds |
|---|---|---|
| Manufactuirng and IND-enabling studies for Leptin product | $200,000 | 8.0% |
| Phase 1A/1B clinical trials | $2,102,000 | 84.1% |
| Personnel costs | $25,500 | 1.0% |
| Debt repayment | $50,000 | 2.0% |
| Intermediary fees | $122,500 | 4.9% |
Terms
This is a side-by-side offering of Common Stock, under registration exemptions 4(a)(6) and 506(c), in Neurotez Inc.. Up to $500,000 may be raised under the 4(a)(6) exemption. Netcapital will determine which exemption applies to your investment and notify you before you complete your investment.
The amount raised under the two exemptions must total at least $10,000 by June 24, 2021 at 12:59am ET. If the total doesn’t reach its target, then your money will be refunded. Neurotez Inc. may issue additional securities to raise up to $2,500,000, the offering’s maximum.
If the side-by-side offering is successful at raising the maximum amount, then the company’s implied valuation after the offering (sometimes called its post-money valuation) will be:
Pitch Deck
Financials
These financial statements have been reviewed by an independent Certified Public Accountant.
SEC Filings
The Offering Statement is a formal description of the company and this transaction. It’s filed with the SEC to comply with the requirements of exemptions 4(a)(6) and 506(c) of the Securities Act of 1933. Similar information is sometimes offered in a Private Placement Memorandum for 506(c) offerings.
We’re also required to share links to each of the SEC filings related to this side-by-side offering with investors.
Understand the Risks
Be sure to understand the risks of this type of investment. No regulatory body (not the SEC, not any state regulator) has passed upon the merits of or given its approval to the securities, the terms of the offering, or the accuracy or completeness of any offering materials or information posted herein. That’s typical for Regulation CF offerings like this one.
Neither Netcapital nor any of its directors, officers, employees, representatives, affiliates, or agents shall have any liability whatsoever arising from any error or incompleteness of fact or opinion in, or lack of care in the preparation or publication of, the materials and communication herein or the terms or valuation of any securities offering.
The information contained herein includes forward-looking statements. These statements relate to future events or to future financial performance, and involve known and unknown risks, uncertainties, and other factors, that may cause actual results to be materially different from any future results, levels of activity, performance, or achievements expressed or implied by these forward-looking statements. You should not place undue reliance on forward-looking statements since they involve known and unknown risks, uncertainties, and other factors, which are, in some cases, beyond the company’s control and which could, and likely will, materially affect actual results, levels of activity, performance, or achievements. Any forward-looking statement reflects the current views with respect to future events and is subject to these and other risks, uncertainties, and assumptions relating to operations, results of operations, growth strategy, and liquidity. No obligation exists to publicly update or revise these forward-looking statements for any reason, or to update the reasons actual results could differ materially from those anticipated in these forward-looking statements, even if new information becomes available in the future.
More Info
Updates
- Jan 26, 2023Additonal evidence supports the potential for...
- Dec 10, 2022Join us tomorrow: BIOTECH PLANET International...
- Nov 23, 2022From the President and CEO, Nikolaos...
- Oct 13, 2022We are pleased to share with you that we are...
- Oct 13, 2022Join me at: ...
- Sep 9, 2022We are very delighted to announce the addition...
- Jun 24, 2021Primary offering finalized, selling shares
- Jun 23, 2021Thank you to all Neurotez investors and...
- May 19, 2021Neurotez participating at the Clinical Trials...
- Feb 23, 2021#Neurotez envisages opening a French European...
- Feb 23, 2021Neurotez has been nominated as one of the most...
- Feb 26, 2018Primary offering finalized, selling shares
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